Founded in 1992, the Commission for Orthodox Missions and Evangelism (C.O.M.E.) was organized to educate and engage the faithful of the Metropolis in Evangelism and Mission to: fulfill the Great Commission of Christ (Matthew 28:19-20); assist in the establishment and growth of mission parishes to achieve self sufficiency; further the work and programs of the Orthodox Christian Mission Center (O.C.M.C.) in St. Augustine, Florida, and work to enhance inter-jurisdictional cooperation in the establishment of domestic mission parishes.

The Board of the Commission is chaired by His Eminence Metropolitan Gerasimos and is composed of up to fifteen members both clergy and laity who are responsible for overall policy. It usually meets twice a year.

The Commission works to engage the Orthodox faithful of the Metropolis in understanding that we are all called to make disciples, to “proclaim the message of God's reality, and lead others to that reality through incorporation into the Church.”

The Commission assists in the planting of new parishes in urban/suburban areas which will serve the needs of the Greek Orthodox faithful, potential converts, inactive Orthodox, and the unchurched. The location of the new mission parish is determined by the demographics and the needs as identified by the local leadership. In cities or towns with a small Orthodox population the Commission works with the laity as they gather potential members, experience monthly or bimonthly liturgies, and plan for the future assignment of a full time priest.

COME has helped to establish the full time parishes of Holy Apostles Church in Shoreline, Washington; St. John the Baptist Church in Beaverton and St, George Church in Eugene, Oregon; St. Andrew Church in San Luis Obispo, St. Nicholas Church in Temecula, St. Anna Church in Roseville, and the Greek Orthodox Mission of South Orange County in San Juan Capistrano, California; the Greek Orthodox Mission of Flagstaff, and the Greek Orthodox Mission of Prescott, Arizona.

It also nurtures the growth of the Greek Orthodox mission churches in Pasco Washington, Salem Oregon, Redding California, Sierra Vista Arizona and Maui Hawaii.

In addition, COME has provided support to Mission efforts in Alaska, Africa, Ukraine, and South America.

The Commission receives funds for its work from Pennies and Prayers a joint mission awareness program with the Metropolis Philoptochos Society, from parish and individual donations, and from the Sts. Katherine and George Mission Endowment of the Metropolis of San Francisco.